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Brief Case Report
- Chordoid Meningioma in a Pediatric Patient with Tuberous Sclerosis Complex
- Jiwon Lee, Hee Joon Yu, Jeehun Lee, Ji Hye Kim, Hyung Jin Shin, Yeon-Lim Suh, Munhyang Lee
- Korean J Pathol. 2014;48(4):302-306. Published online August 26, 2014
- DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.4.302
- 7,384 View
- 34 Download
- 3 Crossref
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Citations
Citations to this article as recorded by
- Somatic mutation landscape in a cohort of meningiomas that have undergone grade progression
Sarah A Cain, Bernard Pope, Stefano Mangiola, Theo Mantamadiotis, Katharine J Drummond
BMC Cancer.2023;[Epub] CrossRef - Innumerable Meningiomas Arising in a Patient With Tuberous Sclerosis Complex Decades After Radiation Therapy
Ahmed Gilani, Julieann C Lee, BK Kleinschmidt-DeMasters
Pediatric and Developmental Pathology.2021; 24(5): 471. CrossRef - Predictors of recurrence in the management of chordoid meningioma
Winward Choy, Leonel Ampie, Jonathan B. Lamano, Kartik Kesavabhotla, Qinwen Mao, Andrew T. Parsa, Orin Bloch
Journal of Neuro-Oncology.2016; 126(1): 107. CrossRef
- Somatic mutation landscape in a cohort of meningiomas that have undergone grade progression
Original Article
- p53 Expression and Ki-67 Labeling Index in Brain Tumor with Special Reference to Tumor and Histologic Grade.
- Duck Hwan Kim, Yeon Lim Suh, Dong Ik Shin, Hyung Jin Shin, Jong Hyun Kim
- Korean J Pathol. 1998;32(2):81-87.
- 2,947 View
- 80 Download
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Abstract
PDF - Mutation in the p53 suppressor gene is the most common genetic alteration found in human cancers including primary brain tumors. Ki-67 labeling index(LI) is known to be a marker of proliferating activity. The purpose of this study was to verify whether an immunohistochemical expression of p53 antibody and Ki-67 LI could be related to different clinicopathologic parameters including histologic grade, size, invasiveness and recurrence of the brain tumors. Materials were based on the 147 surgically resected brain tumors during the last two years. Of the 147 brain tumors, there were 35 astrocytic tumors, 35 meningiomas, 10 oligodendrogliomas, 7 craniopharyngiomas, 5 dysembryoplastic neuroepithelial tumors, 4 medulloblastomas, 5 ependymomas, 23 pituitary adenomas, 9 schwannomas, and 14 other brain tumors. The p53 expression and Ki-67 LI were higher in malignant brain tumors including astrocytic tumors, medulloblastoma, PNET and gliosarcoma. The p53 positivity was correlated with histologic grades and tumor recurrence. The brain tumors with a high Ki-67 LI(>6%) also showed a close relationship to a higher histologic grading, radiological invasiveness and recurrence. There was no evident correlation with the age and tumor size with p53 expression and Ki-67 LI. These results suggest that p53 overexpression and high proliferation potential of the tumor cells are associated with the higher histologic grade and aggressive clinical course in the central nervous system tumors.
Case Report
- Pineal Anlage Tumor: A case report.
- Jong Sun Choi, Hyung Jin Shin, Yeon Lim Suh
- Korean J Pathol. 2000;34(12):1029-1033.
- 1,828 View
- 50 Download
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Abstract
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- The term "pineal anlage tumor" has been recently proposed and few cases have been reported. We report the first Korean case of pineal anlage tumor in a 6-year-old girl who complained of headache and vomiting for 2 months. Brain MRI revealed a well defined, lobulated, calcifying mass in the pineal region. Tumor was totally removed. Pathological examination revealed a primitive pineal parenchymal tumor with melanotic epithelial component that was similar to histologic findings of melanotic neuroectodermal tumor of infancy, so-called retinal anlage tumor and of the developing pineal gland. The tumor was composed mostly of small, undifferentiated cells, Flexner-Wintersteiner rosettes, and ganglionic differentiation. The tumor also contained the cartilage and skeletal muscle cells.
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